Breaking down the technical barriers to NAD+ supplementation, VIIVA is leading the global anti-aging revolution with its scientific expertise


TAIPEI, April 8, 2022 /PRNewswire/ — VIIVA has launched the active superfood ingredient, VIIVA NAD+ DIRECT, which can boost the absorption of NAD+ (nicotinamide adenine dinucleotide) and advance the global anti-aging revolution. Throughout history, humans have explored the myth of eternal youth, while anti-aging has become a research topic of eternal interest. As one of the finest achievements of emerging anti-aging research, NAD+ is highly marketed and best known.

NAD+ is an essential substance in the human body. It is involved in thousands of redox enzymatic reactions. Without it, we would be dead in seconds. However, NAD+ levels drop dramatically with age. Between the ages of 40 and 60, at least 50% of NAD+ is lost, leading to accelerated aging and various diseases.

Therefore, at the frontiers of scientific research, the main question of restoring NAD+ levels has become an important research topic. Scientists are interested in the prevention and treatment of age-related diseases, as well as the restoration of health and vitality during the aging process.

With nearly 120 years of landmark research since 1904, three scientists have won Nobel Prizes for their work on NAD+, and eight Nobel Laureates have publicly supported NAD+.

How to Supplement NAD+, the Nobel Prize Winning Substance

According to the conventional understanding, due to its high molecular weight, NAD+ is unstable in air and difficult to penetrate the cell membrane, to be completely absorbed. The only way so far was direct supplementation by intravenous injection, but this method was both invasive and expensive (about ¥5,000/injection, continuous weekly injection) which made those who wanted to fight against aging flinch.

In this regard, researchers began looking for ways to indirectly supplement NAD+. For example, NMN and NA supplements have become popular. These NAD+ supplements have been hailed as “anti-aging elixirs” since their inception. personalities from warren buffet for Li Ka-shing, along with many big names in the business world, have endorsed them.

Aren’t there any direct and effective NAD+ supplements besides these?

Break the technical bottleneck and make the impossible possible

In fact, scientists themselves have researched effective ways to increase NAD+ levels by taking the supplements orally themselves.

In 2001, a biochemistry research team from the University of Genoa, Italy, found that connexin cx43 in half-channels regulates transmembrane flux of intact NAD+ by mediating calcium ions. However, these results were not well received by the medical community. Most medical research was still focused on the conversion of NAD precursors.

During 2016-2018, the Australian Institute of Integrative Medicine proposed the direction of NAD development in the 21st century, namely the formulation of supplements of optimal NAD+ compounds. The optimal direct NAD+ supplement formula can be mediated through transmembrane proteins by combining the encapsulated and stable NAD+ molecules with the natural ingredients that can be effectively combined.

In 2018, a precise and comprehensive pathway for NAD+ transmembrane proteins was again proposed by Italian scientists. Meanwhile, a newly discovered transmembrane protein that can directly transport NAD+ into mitochondria has also been proposed.

At the same time, VIIVA’s Global Product and Science Advisory Board began conducting extensive research into NAD+ supplementation in the NMN study. As the research progressed, the scientists made a new discovery in order to break the technical bottleneck. The goal, of course, was to get direct NAD+ supplementation.

In 2020, the VIIVA Global Product and Science Advisory Board, the Australian College of Eastern Medicine and the Australian Institute of Integrative Medicine jointly set out to develop an NAD+ compound that can be directly absorbed and utilized by the human body.

“It is a fusion of eastern and western wisdom, the concept of homeopathy + the eastern theory of compound formula based on compatibility, based on western molecular medicine”. Sir. Ashley Daymana scientist from the Australian College of Eastern Medicine, said: “Based on this, we have again made a breakthrough in compatibility research and developed the current optimal formula to transform it into an active superfood ingredient, VIIVA NAD+ DIRECT! I believe this will give rise to an innovative, even revolutionary, game-changing product in the field of anti-aging!”

As noted, these progressive steps in scientific research and technological development are only now beginning to reveal how we can take full advantage of its abundant benefits for the benefit of mankind.

Subversive research findings usher in a new era with direct supplementation

The result of VIIVA’s latest research, NAD+ DIRECT, uses original DRT technology to innovatively solve the problem of oral absorption of NAD+.

“NAD+ Direct was formulated by a team of Chinese physicians trained in the timeless principles of Traditional Chinese Medicine. Ingredients were chosen based on their energy compatibility with the goal of increasing blood and chi strength in people who use them.Western medical science was used to design and develop a physical product that contained a supplement payload wrapped in several layers of lipids.The outermost layer is a preparation that resists temperature fluctuations so that the product can be safely stored at room temperature.The second lipid capsule protects its contents against the action of stomach acid and intestinal digestive enzymes.At an ideal position in the small intestine, the second protective shell dissolves and opens into another third lipid layer which facilitates absorption and transport from the capsule into, then to t in the cells that line the intestine and in the small blood vessels. Once in the bloodstream, the product, using newly developed cell-penetrating technology, enters the cell with the unmodified NAD+ molecule of the NAD+ molecule that was taken orally. This total manufacturing process is innovative and patentable because it does, theoretically, something that no other supplement preparation can do; that is, allows oral NAD+ to be transported intact into the cells where it is used. Another ingredient, PQQ, enters the cell separately from NAD+ and enhances the recycling of NAD+ in what is called a “salvage pathway” from the cytosol. The last major ingredient, urolithin A, also enters the cell separately and helps recycle mitochondria, the intracellular organelles that produce ATP, the body’s energy. NAD+ is essential for the production of ATP by the mitochondria. NAD+ Direct is therefore a unique product where the Eastern wisdom of Traditional Chinese Medicine has been integrated with the science of Western Medicine to form a powerful NAD+ supplement that has a powerful impact on human health. proudly declares Chief Advisor Dr. Fred Templeman of VIIVA’s Global Product and Science Advisory Board.

VIIVA NAD+ DIRECT provides direct oral NAD+ supplementation and directly delivers energy to the mitochondria to achieve the optimal balance of NAD+ levels in the human body. VIIVA launched this product to offer consumers a new approach to anti-aging. Considering direct NAD+ supplementation and the unique technology behind it, VIIVA NAD+ DIRECT will be a superior choice among all other NAD+ supplements!



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