TORONTO, Feb. 16 2022 (GLOBE NEWSWIRE) — PharmaTher Holdings Ltd. (the “Company” or “PharmaTher”) (OTCQB: PHRRF) (CSE: PHRM), a leader in ketamine-based specialty pharmaceuticals, is pleased to announce that the United Nations Patent and Trademark Office United States granted the company U.S. Patent No. 11,213,495, titled “Method and Composition for Reducing the Psychotomimetic Side Effect and Addictive Disorder of Ketamine.” The patent refers to the FDA-approved combination formulation of ketamine and betaine anhydrous (“KETABET™”), which has been shown in research to enhance antidepressant effect while potentially reducing the known negative side effects of ketamine. .
“We are extremely pleased with the granting of this patent in the United States as it further validates the potential of KETABET™, strengthens our intellectual property position and underscores our commitment to ketamine innovation for mental health, neurological disorders and pain,” said Fabio. Chianelli, CEO of PharmaTher.
The granted patent strengthens the Company’s global patent portfolio. It offers broad potential of KETABET™ for uses in various mental health, neurological and pain disorders, and new forms of delivery, including the patented hydrogel-forming microneedle patch delivery system of the society.
Additionally, issued patents for KETABET™ are issued in Japan (Patent No. 6967532) and Taiwan (Patent No. I648049). The Company plans to convert current patent applications in Europe, Canada, Israel and China into issued patents. Patent protection is expected to expire in 2036.
Granted patents and published studies further validate the potential of KETABET™ and support ongoing observational studies by company researchers evaluating the impact of betaine on adverse ketamine side effects seen after ketamine treatment in subjects suffering from depression or pain. Based on the results of ongoing studies, the Company will advance the KETABET™ program with its micro-needle patch technology into Phase 2 clinical studies.
The company previously announced the publication of a scientific paper demonstrating the potential of KETABET™ to prevent the potential adverse psychiatric effects of repeated ketamine treatment for depression and other indications, including suicidal ideation, substance abuse, post-traumatic stress disorder and chronic pain. The article titled “Betaine Prevents and Reverses Behavioral Deficits and Synaptic Dysfunction Induced by Repeated Ketamine Exposure in Mice”, is published in Biomedicine & Pharmacotherapy and can be found here.
About PharmaTher Holdings Ltd.
PharmaTher Holdings Ltd. (OTCQB: PHRRF) (CSE: PHRM) is focused on the development and commercialization of ketamine-based specialty pharmaceutical products for mental health, neurological disorders and pain. Learn more about PharmaTher.com.
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